A Fundamentally Different Approach to Treating Inflammatory Disease

Targeting the cells that drive tissue damage — not just the inflammatory signals they produce

ARDIA
APPROACH

Targets the Source

Restores cellular function

Repairs tissue and barrier integrity

Accelerates skin healing

Not immunosuppressive

CONVENTIONAL
THERAPIES

Targets the Signals

Inhibits inflammatory cytokines

Immunosuppressant

This approach is designed to restore skin tissue integrity and break the cycle of skin damage from chronic inflammation through cellular differentiation

DIA-615: Hypothesized Mechanistic Pathway

Designed to Restore Healthy Skin Biology

Cellular Stress

Promote proper protein folding and reduce endoplasmic reticulum stress

Epigenetic
Changes

Change gene transcription to restore normal cell function

Tissue Integrity

Support keratinocyte differentiation & restoration of skin barrier function

Immune Sparing

Reduce inflammation
without
suppressing
immune defenses

For partnership and investor inquiries:

Bjones@ardiatherapeutics.com